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KMID : 0357920050390050320
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Korean Journal of Pathology
2005 Volume.39 No. 5 p.320 ~ p.325
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Survivin and Fas Ligand Expressions Are Correlated with Angiolymphatic Tumor Spread in Medullary Thyroid Carcinoma
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Kim Min-Kyoung
Park Sung-Hye
Joo Mee
Sohn Jin-Hee
Chae Seoung-Wan
Park Seong-Hoe
Kim Han-Seung
Kim Eo-Jin
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Abstract
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Background: Medullary thyroid carcinoma (MTC) that originates from C cells comprises about 10% of all the malignant thyroid tumors. Activating mutations of the RET proto-oncogene have been found to be involved in the anti-apoptotic pathway of MTC that harbors the RET mutation. We investigated the correlation between the clinicopathologic parameters and the expressions of survivin, a novel anti-apoptotic molecule, and the other apoptosis-related proteins, and the known prognostic markers.
Methods: Immunohistochemical staining was performed using antibodies for survivin, Fas, Fas ligand (FasL), bcl-2, calcitonin, CEA and cyclin A in 19 case of MTC; 10 sporadic MTCs, eight multiple endocrine neoplasia (MEN) type 2A MTCs and one
familial MTC (FMTC).
Results: Survivin protein expression was found in five cases (26%) and this was correlated with the presence of angiolymphatic tumor emboli (p=0.019). FasL was expressed in 14 cases (74%) and it had correlation with the presence of lymph node metastases (p=0.029). The cyclin A-labeling indices were correlated with local invasiveness (p=0.001).
Conclusions: Survivin and FasL might be involved in the lymphatic tumor spread of MTC.
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KEYWORD
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Survivin protein, Thyroid gland, Carcinoma, medullary
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